RECoVER Household Extension Study
Study profileDescription
The sponsor had a cohort of ~330 households with children who had been prospectively followed since September 2020 for SARS-CoV-2 infections. The study infrastructure was utilised in VERDI to rapidly extend data collection. Data were collected on household and individual characteristics, and occurrence of SARS-CoV-2 infection in household members were ascertained during follow-up using virological and serological evaluation, along with daily recording of infection symptoms. Data were reported directly by study participants.
Sponsor: UMC Utrecht
Countries involved: The Netherlands
Sample size: 276 households (first cohort); 63 households (second cohort)
Related publications:
- Westerhof I, de Hoog M, Ieven M, Lammens C, van Beek J, Rozhnova G, Eggink D, Euser S, Wildenbeest J, Duijts L, van Houten M, Goossens H, Giaquinto C, Bruijning-Verhagen P. The impact of variant and vaccination on SARS-CoV-2 symptomatology; three prospective household cohorts. Int J Infect Dis. 2023;128:140-147. doi:10.1016/j.ijid.2022.12.018
- Westerhof I, Sikkema R, Rozhnova G, van Beek J, Koopmans M, Bruijning-Verhagen P. The effect of pre-existing coronavirus antibodies on SARS-CoV-2 infection outcomes in exposed household members. J Infect Dis. 2025;232(2):e318-e326. doi:10.1093/infdis/jiaf172
- de Hoog MLA, Hauser-van Westrhenen ESEM, Winkel AMAM, de Jong MD, van Houten MA, van Lelyveld SFL, Eggink D, Euser S, Duijts L, Wildenbeest JG, Schuurman R, van de Wijgert JHHM, Ieven M, Loens K, van der Velden AW, Bonten MJM, Goossens H, Bruijning-Verhagen PCJL. Impact of co-infection with SARS-CoV-2 and other respiratory viruses on illness: Pooled analyses of 11 COVID-19 cohorts. J Infect. 2025;90(6):106501. doi:10.1016/j.jinf.2025.106501
Metadata collected
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| Data collected? | |
| Demographics | |
| Date of birth (full or MM/YY) | |
| Age at contact | ✅ |
| Sex / gender | ✅ |
| Country of birth | ✅ |
| Ethnic group / race / population sector | |
| Income level | |
| Employment / occupation | |
| Other socio-economic status proxy | |
| Education level | ✅ |
| Civil status (‘marital’) | |
| Locality (of health care provision) | |
| Locality (of residence) | ✅ |
| Household size | ✅ |
| Household composition | ✅ |
| Hospitalisation | |
| Admission / discharge dates or duration | |
| Episode dates | |
| Episode type (e.g., general; birth) | |
| Diagnosis (e.g., codes) | |
| Procedures (e.g., codes) | |
| Procedures dates | |
| Dispensed medications | |
| ICU admission | ✅ |
| Admission type (planned/emergency) | |
| Hospitalisation for COVID-19 | ✅ |
| Primary care, outpatient care | |
| Date of visit / contact | ✅ |
| Diagnosis codes | |
| Dispensed medications codes | |
| Dispensed medications date | |
| Primary care utilisation summary | |
| Health status and exposures | |
| Height | ✅ |
| Weight | ✅ |
| Date of anthropometrics | |
| Chronic / co-morbid conditions~ | ✅ |
| Medications for chronic conditions | ✅ |
| Smoker in household | ✅ |
| Current smoker | ✅ |
| ~ can include obesity | |
| Vaccines | |
| COVID-19 vaccine (timing, doses) | ✅ |
| Type of COVID-19 vaccine | ✅ |
| Other vaccinations / vaccination history | |
| COVID-19 symptoms & contacts | |
| COVID-19 episodes | ✅ |
| COVID-19 symptoms (type, severity, duration) | ✅ |
| Influenza-like symptoms (type, timing, duration) | ✅ |
| COVID-19 health-seeking behaviour | ✅ |
| COVID-19 contacts in household | ✅ |
| Medications during C-19 episode | ✅ |
| Pregnancy & birth | |
| Date of delivery | |
| Length of gestation | |
| Birthweight | |
| Maternal age at delivery | |
| Pregnancy complications | |
| Smoking pre-pregnancy | |
| Vaccines in pregnancy (non-COVID-19) | |
| Parity / nulliparity | |
| Pre-pregnancy body mass index | |
| Pregnancy outcome (e.g. miscarriage) | |
| Mode of delivery | |
| Sex of baby | |
| Congenital anomalies | |
| Other newborn complications | |
| Placental weight | |
| Antenatal care usage | |
| Currently pregnant | |
| Death | |
| Date of / age at death | |
| Cause of death | |
| COVID-19 laboratory tests | |
| Sample type tested | ✅ |
| Sample / specimen collection date | ✅ |
| SARS-CoV-2 PCR test date | ✅ |
| SARS-CoV-2 PCR pos / neg result | ✅ |
| SARS-CoV-2 PCR Ct Value | ✅ |
| SARS-CoV-2 LFT test date | ✅ |
| SARS-CoV-2 LFT test result | ✅ |
| Serology test date | ✅ |
| Serology test results | ✅ |
| SARS- COV-2 genomic test results | |
| SARS- COV-2 variant/ lineage | |
| Other lab tests | |
| COVID-19 sample collection / storage | |
| Sample type collected | ✅ |
| Sample collection date | ✅ |
| Sample collection time | ✅ |
| Sample processing | |
| Sample quality | |
| Consent to use research sample | |
| Consent to share research sample |