Work Package 1 is responsible for ensuring successful project oversight, management and coordination. Its work encompasses supervising operations, implementing day-to-day work plans and ensuring that all project deliverables and milestones are delivered on time. It also focuses on quality assurance, risk management, and compliance with the European Commission's requirements.

WP1 is led by University of Padua, in collaboration with Penta Foundation and University College London.

Work Package 2 is responsible for tracking SARS-CoV2 variants and mpox cases in paediatric, pregnant and other high risk populations, through the establishment of a global network of laboratories and a virtual biobank for virological and immunological assessment.

WP2 is led by University College London, in collaboration with University of Antwerp and support from Penta Foundation, Istituto Zooprofilattico Sperimentale delle Venezie and University of Liège.

Work Package 3's aim is to understand how SARS-CoV-2 variants of concern influence the severity of COVID-19 disease and treatment outcomes, transmission, and treatment and vaccination strategies for children and pregnant women, as well as to understand the epidemiology, risk factors and outcomes of patients with mpox in VERDI cohorts.

WP3 is led by University College London, with participation of all VERDI cohorts and in collaboration with UMCU, Penta, ISI, SU, MU, CMU, GHESKIO, UNIBAS, UKBB, UO, Pedianet and UTARTU.